In humans, CoA biosynthesis requires cysteine, pantothenate (vitamin B5), and adenosine triphosphate (ATP). (, pyruvoyl group This section provides a listing of alternate names for this chemical, Used to make other chemicals. Methylmalonyl-CoA mutase (MCM), mitochondrial, also known as methylmalonyl-CoA isomerase, is a protein that in humans is encoded by the MUT gene. On a molecular level, the odd-chain fatty acids are biosynthesized and metabolized slightly differently from the even-chained relatives. [7] This mechanism is shown below to the left along with the participating reactants, products, intermediates, and enzymes. Suppliers. 1 Business Cooperation [11], Propionyl-CoA has can have many adverse and toxic affects on different species, including bacterium. Disclaimer, Copyright © 2013-2020 MOLBASE All Rights Reserved ICP Shanghai 14014220, Lead Time: Based on a scenario where the chemical is spilled into an excess of water (at least 5 fold excess of water), half of the maximum theoretical yield of Hydrogen Chloride gas will be created in 0.09 minutes. In mammals, propionyl-CoA is converted to (S)-methylmalonyl-CoA by propionyl-CoA carboxylase, a biotin-dependent enzyme also requiring bicarbonate and ATP. This radical then goes on to abstract a hydrogen from the previously produced 5'-deoxyadenosine, again creating a deoxyadenosyl radical, which attacks the coenzyme to reform the initial complex. Instead, catabolism proceeds through propionyl-CoA carboxylase. All genomes sequenced to date encode enzymes that use coenzyme A as a substrate, and around 4% of cellular enzymes use it (or a thioester) as a substrate. Since different cycles have been proposed regarding how propionyl-CoA is transformed into pyruvate, one studied mechanism is the methylcitrate cycle.The initial reaction is beta-oxidation to form the propionyl-CoA which is further broken down by the cycle. Most fatty acids are even chain, e.g. Structure, properties, spectra, suppliers and links for: Propionyl phosphate. E EINECS No. Newborns are tested for elevated propionylcarnitine. Brown, H.M. Hartmann, W.A. Synonyms. Any donor that can transfer acyl groups between molecular entities. Articles of 3-(2-nitro-phenyl)-propionyl … +86-400-6021-666; ; Sign in; Register; About Us; Chinese; Search Batch Search. IUPAC Name: N'-phenylpropanehydrazide . Therefore, odd-number chains of, Propionyl-CoA is not only produced from the oxidation of odd-chain fatty acids, but also by the oxidation of. J Its central importance to many biochemical pathways suggests that it was one of the earliest components of metabolism and may have originated abiogenically. [1] Several different pathways can lead to its production, such as through the catabolism of specific amino acids or the oxidation of odd-chain fatty acids. (. PCC not only catalyzes the carboxylation of propionyl-CoA to methylmalonyl-CoA, but also acts on several different acyl-CoAs. H Coenzyme A (CoA, SHCoA, CoASH) is a coenzyme, notable for its role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. Y Vigorously reacts with water to form propionic acid and hydrochloric acid [Merck 11th ed. 8 Propionyl-CoA is a coenzyme A derivative of propionic acid. Molecular Formula C. 3. See: 3-hydroxy-3-(3-hydroxy-4-methoxyphenyl)propanoyl-CoA A lack of such catabolism would therefore increase the susceptibility of the cell to various toxins, particularly to macrophage antimicrobial mechanisms. The enzyme is biotin-dependent. The oxidation of propionyl-CoA to form pyruvate is influenced by its necessity in Mycobacterium tuberculosis . N In a study concerning Aspergillus nidulans , it was found that with the inhibition of a methylcitrate synthase gene, mcsA, of the pathway described above, production of distinct polyketides was inhibited as well. Molecular formula. : 79-03-8. It is an enzyme associated with Malonyl-CoA decarboxylase deficiency. In humans, it is encoded by the MLYCD gene. [7], Within the citric acid cycle in humans, propionyl-CoA, which interacts with oxaloacetate to form methylcitrate, can also catalyzed into methylmalonyl-CoA through carboxylation by propionyl-CoA carboxylase (PCC). Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.